The systematic review was searched by the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses method. All trials reporting the use of negative pressure wound therapy for surgical site infection treatment were included regardless of surgery type. The primary outcome measure was wound healing. Secondary outcomes were length of hospital stay, medical costs, adverse events, and reoperation rates. Results are presented with 95% confidence intervals and report estimates as odds ratios. Heterogeneity was determined through the I2 test, with I2 > 50% indicating substantial heterogeneity and p < .10 significance. The search was performed on 10 March 2020.