NEURAL REGENERATION RESEARCH

Vol 20｜No. 8｜August 2025

封面设计理念

此次设计充满了西方和东方的象征意义，代表了我们在中枢神经系统细胞疗法方面的研究成果。背景分别用黑色/白色和绿色/蓝色的花朵代表死亡和健康。剑是双刃的，其颜色也有编码，红色代表炎症和火焰，蓝色代表生存。剑柄上刻有阴/阳图案，象征着细胞疗法的双重作用。剑柄是一个天平，说明了细胞死亡和炎症（左）与神经元挽救（右）之间的微妙平衡。这把剑是中世纪西班牙骑士 El Cid Campeador 的佩剑 "La Tizona "，这不仅是对我们国家的致敬，也是对科学家也是抗击疾病的骑士这一事实的致敬。

综述

Interaction of major facilitator superfamily domain containing 2A with the blood–brain barrier

主要促进因子超家族成员2A与血脑屏障的互作

Yilun Ma, Taiwei Dong, Fei Luan, Juanjuan Yang, Feng Miao, Peifeng Wei

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery

工程化细胞外囊泡作为缺血性脑卒中的递送载体：线粒体递送的前景

Jiali Chen, Yiyang Li, Xingping Quan, Jinfen Chen, Yan Han, Li Yang, Manfei Zhou, Greta Seng Peng Mok, Ruibing Wang, Yonghua Zhao

Neuroprotective potential for mitigating ischemia-reperfusioninduced damage

脑缺血再灌注损伤中Sirtuins的神经保护潜力

Zi Ye, Runqing Liu, Hangxing Wang, Aizhen Zuo, Cen Jin, Nan Wang, Huiqi Sun, Luqian Feng, Hua Yang

Bidirectional regulation of the brain–gut–microbiota axis following traumatic brain injury

创伤性脑损伤后脑-肠-微生物轴的双向调节

Xinyu You, Lin Niu, Jiafeng Fu, Shining Ge, Jiangwei Shi, Yanjun Zhang, Pengwei Zhuang

C–C motif chemokine ligand 2/C–C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

CCL2/CCR2通路成为脊髓损伤治疗靶点和调控方式的可能性

Xiangzi Wang, Xiaofei Niu, Yingkai Wang, Yang Liu, Cheng Yang, Xuyi Chen, Zhongquan Qi

Neuronal regulated cell death in aging-related neurodegenerative diseases: key pathways and therapeutic potentials

神经元衰老相关神经退行性疾病中调节性细胞死亡：关键通路和治疗潜力

Run Song, Shiyi Yin, Jiannan Wu, Junqiang Yan

Glycolytic dysregulation in Alzheimer’s disease: unveiling new avenues for understanding pathogenesis and improving therapy

糖酵解失调：阿尔茨海默病发病机制和治疗新靶点

You Wu, Lijie Yang, Wanrong Jiang, Xinyuan Zhang, Zhaohui Yao

Decoding molecular mechanisms: brain aging and Alzheimer’s disease

解码分子机制：大脑衰老与阿尔茨海默病

Mahnoor Hayat, Rafay Ali Syed, Hammad Qaiser, Mohammad Uzair, Khalid Al-Regaiey, Roaa Khallaf, Lubna Abdullah Mohammed Albassam, Imdad Kaleem, Xueyi Wang, Ran Wang, Mehwish S. Bhatti, Shahid Bashir

Diabetic peripheral neuropathy and neuromodulation techniques: a systematic review of progress and prospects

糖尿病周围神经病变和神经调节技术：进展和前景的系统评价

Rahul Mittal, Keelin McKenna, Grant Keith, Evan McKenna, Joana R. N. Lemos, Jeenu Mittal, Khemraj Hirani

Interconnections between diabetic corneal neuropathy and diabetic retinopathy: diagnostic and therapeutic implications

糖尿病性角膜神经病变与糖尿病性视网膜病变之间的相互联系：诊断和治疗意义

Mingyi Yu, Faith Teo En Ning, Chang Liu, Yu-Chi Liu

观点

Neurocircuit regeneration by extracellular matrix reprogramming

通过细胞外基质重编程实现神经环路再生

Shengzhang Su, Ian N. Levasseur, Kimberly M. Alonge

Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

改变的磷酸二酯酶 2 依赖性信号在认知型脑部疾病的病理生理学中起着核心作用

Asma Boulksibat, Alessandra Tempio, Barbara Bardoni

Impact of Zika virus non-structural protein mutations on hippocampal damage

寨卡病毒非结构蛋白突变对海马损伤的影响

Larissa M. G. Cassiano, Roney S. Coimbra

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

利用先进的微系统解读创伤性脑损伤中小胶质细胞的机械生物学

Anthony Procès, Sylvain Gabriele

In vivo direct neuronal conversion as a therapeutic strategy for ischemic stroke

体内直接神经元转化作为缺血性卒中的治疗策略

Takashi Irie, Taito Matsuda

Brain age estimation: premise, promise, and problems

大脑年龄估计：前提、前景和问题

Jarrad Perron, Ji Hyun Ko

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

核苷修饰的信使核糖核酸脂质纳米粒子作为一种新的脊髓损伤修复递送平台

Krisztián Pajer, Tamás Bellák, Antal Nógrádi

The loaded matrix: neurotrophin-enriched hydrogels for stem cell brain repair in Parkinson’s disease

加载基质：富含神经营养因子的水凝胶用于帕金森病的干细胞脑修复

Eilis Dowd, Giulia Comini

Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis

卡铂可恢复 FUS 相关肌萎缩侧索硬化的神经元毒性

Kiyoung Kim

Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration

额颞叶变性患者血清纤溶酶原激活物抑制物-1水平升高的机制

Francesco Angelucci, Jakub Hort

Making bridges between preclinical and clinical insights into age-related cognitive decline

在与年龄相关的认知能力下降的临床前和临床见解之间架起桥梁

David VC Brito, Clévio Nóbrega

Understanding activity of butyrate at a cellular level

了解丁酸在细胞水平上的活性

Prapti Chakraborty, Angela S. Laird

研究原著

脑损伤与神经再生

Hypidone hydrochloride (YL-0919) ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

盐酸羟哌吡酮YL-0919改善创伤性脑损伤小鼠功能障碍的抗氧化作用

Yafan Bai, Hui Ma, Yue Zhang, Jinfeng Li, Xiaojuan Hou, Yixin Yang, Guyan Wang, Yunfeng Li

脊髓损伤与神经再生

Passive activity enhances residual control ability in patients with complete spinal cord injury

被动活动可增强完全性脊髓损伤患者残余运动的控制能力

Yanqing Xiao, Mingming Gao, Zejia He, Jia Zheng, Hongming Bai, Jia-Sheng Rao, Guiyun Song, Wei Song, Xiaoguang Li

神经退行性疾病与神经再生

Effects of P301L-TAU on posttranslational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

P301L-Tau 对人类 iPSC来源的皮质神经元和 Tau 转基因小鼠微管蛋白翻译后修饰的影响

Mohamed Aghyad Al Kabbani, Christoph Köhler, Hans Zempel

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease

调控cGAS-STING-干扰素调节因子 7通路对帕金森病神经炎症的影响

Shengyang Zhou, Ting Li, Wei Zhang, Jian Wu, Hui Hong, Wei Quan, Xinyu Qiao, Chun Cui, Chenmeng Qiao, Weijiang Zhao, Yanqin Shen

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

长期保存的血浆样品中神经退行性疾病生物标志物浓度和诊断效能可受到影响

Lifang Zhao, Mingkai Zhang, Qimeng Li, Xuemin Wang, Jie Lu, Ying Han, Yanning Cai

周围神经损伤与神经再生

EZH2-dependent myelination following sciatic nerve injury

坐骨神经损伤后EZH2依赖性髓鞘形成

Hui Zhu, Li Mu, Xi Xu, Tianyi Huang, Ying Wang, Siyuan Xu, Yiting Wang, Wencong Wang, Zhiping Wang, Hongkui Wang, Chengbin Xue

视神经损伤与神经再生

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia: a double-edged sword

嗅鞘胶质细胞在视网膜损伤后小胶质细胞抑制治疗中不同反应取决于移植的类型：一把双刃剑（封面文章）

María Norte-Muñoz, María Portela-Lomba, Paloma Sobrado-Calvo, Diana Simón, Johnny Di Pierdomenico, Alejandro Gallego-Ortega, Mar Pérez, José M. Cabrera-Maqueda, Javier Sierra, Manuel Vidal-Sanz, María Teresa Moreno-Flores, Marta Agudo-Barriuso

AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

AAV2-PDE6B 抑制细胞凋亡拯救Rd10 模型小鼠视网膜色素变性

Ruiqi Qiu, Mingzhu Yang, Xiuxiu Jin, Jingyang Liu, Weiping Wang, Xiaoli Zhang, Jinfeng Han, Bo Lei

神经发育与神经再生

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

CNKSR2互作组分析揭示与中心体及微管系统的相关性

Lin Yin, Yalan Xu, Jie Mu, Yu Leng, Lei Ma, Yu Zheng, Ruizhi Li, Yin Wang, Peifeng Li, Hai Zhu, Dong Wang, Jing Li