Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders

间充质干细胞衍生的细胞外囊泡和外泌体miRNA在神经系统疾病中的潜在作用

Masako Nakano, Mineko Fujimiya | Sapporo Medical University School of Medicine, Japan

Inhibition of extracellular vesicles pathway using neutral sphingomyelinase inhibitors as a neuroprotective treatment for brain injury

使用中性鞘磷脂酶抑制剂作为脑损伤的神经保护性治疗抑制细胞外囊泡通路

Asit Kumar, Santosh Kumar | University of Tennessee Health Science Center, USA

Localization of the hydrogen sulfide and oxytocin systems at the depth of the sulci in a porcine model of acute subdural hematoma

硫化氢和催产素系统在猪急性硬膜下血肿模型中沟深的定位研究

Oscar McCook, Angelika Scheuerle, Nicole Denoix, Thomas Kapapa, Peter Radermacher, Tamara Merz | Ulm University Medical Center, Germany

Neuroglobin and neuroprotection: the role of natural and synthetic compounds in neuroglobin pharmacological induction

神经球蛋白与神经保护：天然和合成化合物在神经球蛋白药理诱导中的作用

Lidia Ciccone, Susanna Nencetti, Simone Socci, Elisabetta Orlandini | University of Pisa, Italy

Lithium beyond psychiatric indications: the reincarnation of a new old drug

精神病学指征以外的锂：一种新旧药物的转世

Matteo Haupt, Mathias Bähr, Thorsten R. Doeppner | University Medical Center Göttingen, Germany

Epidural electrical stimulation for spinal cord injury

硬膜外电刺激治疗脊髓损伤

Elliot H. Choi, Sandra Gattas, Nolan J. Brown, John D. Hong, Joshua N. Limbo, Alvin Y. Chan, Michael Y. Oh | Case Western Reserve University, USA

Perspectives

Microglia activation: a role for mitochondrial DNA?

小胶质细胞激活：线粒体DNA的作用？

Marcello Pinti, Diana Ferraro, Milena Nasi | University of Modena and Reggio Emilia, Italy

Exploring genes that control microglial heterogeneity and transition

探索控制小神经胶质细胞异质性和过渡的基因

Tomomi Okajima, Fuminori Tsuruta | University of Tsukuba, Japan

A 3R-Tau-mediated mechanism in oligodendrocytes: could it be the key for neuroprotection after stroke?

少突胶质细胞中3R-Tau介导的机制：它可能是脑卒中后神经保护的关键？

Mario Villa Gonzalez, Maria José Pérez-Álvarez | Universidad Autónoma de Madrid, Spain

Light of the stars: Calcium signals light up astrocytes in the presence of autoreactive CD4+ T cells

点亮星辰：在自身反应性CD4 + T细胞存在的情况下钙信号点亮星形胶质细胞

Jelena Bogdanović Pristov, Ljiljana Nikolić | University of Belgrade, Serbia

Netrin-1 marshals mitochondrial movement, morphology, and metabolism in myelin

Netrin-1在髓鞘中调控线粒体运动、形态和代谢

Diane S. Nakamura, Timothy E. Kennedy | McGill University, Canada

DNMT1-dependent regulation of cortical interneuron function and survival

DNMT1依赖性调节皮层中间神经元功能和存活

Daniel Pensold, Geraldine Zimmer-Bensch | RWTH Aachen University, Germany

Combinatorial genetics methods for discovering high-order regulatory combinations and engineering genetic drivers for neural differentiation

组合遗传学方法可发现高级调控组合并设计神经分化的遗传驱动

Dawn G. L. Thean, Alan S. L. Wong | The University of Hong Kong, China

Open late: neuronal membrane disruption late in traumatic brain injury

开放晚期：创伤性脑损伤晚期神经元膜中断

Martina L. Hernandez, MiJin Cho, Audrey D. Lafrenaye | Virginia Commonwealth University, USA

The antiaging role of oxytocin

催产素的抗衰老作用

Tarek Benameur, Maria A. Panaro, Chiara Porro | University of Foggia, Italy

Caspase-1: an important player and possible target for repair of the blood-brain barrier underlying neurodegeneration

Caspase-1：修复神经变性基础血脑屏障的重要参与者和可能的靶点

Daniel Rand, Itzik Cooper | Sheba Medical Center, Israel

Abnormal metal homeostasis as a common drug target to combat neurodegenerative diseases

异常的金属稳态作为对抗神经退行性疾病的常见药物靶标

Dagmar Pretsch | Oxford Antibiotic Group GmbH, Austria

Advance in the use of gold nanoparticles in the treatment of neurodegenerative diseases: new perspectives

金纳米颗粒在神经退行性疾病治疗中的应用进展：新观点

Gustavo de Bem Silveira, Alexandre Pastoris Muller, Ricardo Andrez Machado-de-Ávila, Paulo Cesar Lock Silveira | Universidade do Extremo Sul Catarinense, Brazil

BACE1 role in Alzheimer's disease and other dementias: from the theory to the practice

BACE1在阿尔茨海默病和其他痴呆症中的作用：从理论到实践

Carlo Cervellati, Giuseppe Valacchi, Giovanni Zuliani | University of Ferrara, Italy

Neurovascular ageing: transcriptomic readout and implications on therapeutic targeting in Alzheimer’s disease

神经血管衰老：转录组读出及其对阿尔茨海默病治疗靶向的影响

Zhongqi Li, Bonaventure Ip, Vincent C. T. Mok, Ho Ko | The Chinese University of Hong Kong, China

Rogue gene networks gone awry in Alzheimer’s disease

阿尔茨海默病中的流氓基因网络出了问题

Emily Miyoshi, Vivek Swarup | University of California, Irvine, USA

A long story for a short peptide: therapeutic efficacy of a cleavage-specific tau antibody

短肽的长话：裂解特异性tau抗体的治疗功效

Giuseppina Amadoro, Valentina Latina, Pietro Calissano | National Research Council (CNR), Italy

A pilot exploration with Posiphen to normalize APP in Down syndrome

用Posiphen进行的先期探索以规范唐氏综合征中的APP

Xu-Qiao Chen | University of California San Diego, USA

Multiple sclerosis: why we should focus on both sides of the (auto)antibody

多发性硬化症：为什么我们要关注（自身）抗体的两方面？

Jeroen den Dunnen, Lynn Mes, Willianne Hoepel, Joost Smolders | University of Amsterdam, The Netherlands

Multiple hurdle mechanism and blood-brain barrier dysfunction in pharmacoresistant epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation

癫痫的多重障碍机制和血脑屏障：糖皮质激素受体-热激蛋白对药物调节的影响

Aneesha Achar, Chaitali Ghosh | Cleveland Clinic, USA

Spinal cord injury: can we repair spinal cord non-invasively by using magnetic stimulation?

脊髓损伤：我们可以通过使用磁刺激非侵入性地修复脊髓吗？

Quentin Delarue, Chaima Chalfouh, Nicolas Guérout | Normandie University, France

研究原著

脑损伤与神经再生

Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey

食蟹猴与小鼠大脑皮质神经元分化发育和电子活性的差异

Xue-Yan Zhang, Jun Li, Cai-Juan Li, Ying-Qi Lin, Chun-Hui Huang, Xiao Zheng, Xi-Chen Song, Zhu-Chi Tu, Xiao-Jiang Li, Sen Yan

A method for using video presentation to increase the vividness and activity of cortical regions during motor imagery tasks

运动想象任务中使用视频演示可增强大脑皮质的生动性和活动性

Kengo Fujiwara, Masatomo Shibata, Yoshinaga Awano, Koji Shibayama, Naoki Iso, Moemi Matsuo, Akira Nakashima, Takefumi Moriuchi, Wataru Mitsunaga, Toshio Higashi

Protein profiling identified mitochondrial dysfunction and synaptic abnormalities after dexamethasone intervention in rats with traumatic brain injury

地塞米松可使创伤性脑损伤大鼠线粒体功能和突触发生异常的蛋白组学分析

Fei Niu, Bin Zhang, Jie Feng, Xiang Mao, Xiao-Jian Xu, Jin-Qian Dong, Bai-Yun Liu

Environmental enrichment combined with fasudil promotes motor function recovery and axonal regeneration after stroke

丰富环境联合法舒地尔可促进缺血性脑卒中后运动功能恢复和轴突再生

Yi-Tong Zhu, Qun Zhang, Hong-Yu Xie, Ke-Wei Yu, Gao-Jing Xu, Si-Yue Li, Yi Wu

SOCS1/JAK2/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses

SOCS1/JAK2/STAT3轴可通过诱导炎症反应参与蛛网膜下腔出血后的早期脑损伤

Yang Wang, Xiang-Qian Kong, Fei Wu, Bin Xu, De-Jun Bao, Chuan-Dong Cheng, Xiang-Ping Wei, Yong-Fei Dong, Chao-Shi Niu

Rutin pretreatment promotes microglial M1 to M2 phenotype polarization

芦丁预处理促进小胶质细胞从M1型向M2型转化

Guang-Ping Lang, Can Li, Ying-Ying Han

Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction

海马胰岛素抵抗与糖尿病诱发认知功能障碍中的Sirtuin 1信号通路

Hui Yang, Lin Tang, Zhan Qu, Shi-Hui Lei, Wei Li, Yu-Hong Wang

脊髓损伤与神经再生

Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching

痉挛蛋白与坍塌反应调节蛋白3相互作用调控神经元的生长和分支

Zhi-Sheng Ji, Jian-Ping Li, Chao-Hua Fu, Jian-Xian Luo, Hua Yang, Guo-Wei Zhang, Wutian Wu, Hong-Sheng Lin

Tensile mechanical analysis of anisotropy and velocity dependence of the spinal cord white matter: a biomechanical study

创伤性脊髓白质损伤后各向异性和速度依赖性的拉伸力学特性

Norihiro Nishida, Itsuo Sakuramoto, Yoshihiro Fujii, Rudolf Yoga Hutama, Fei Jiang, Junji Ohgi, Yasuaki Imajo, Hidenori Suzuki, Masahiro Funaba, Xian Chen, Takashi Sakai

Skeletal muscle stiffness as measured by magnetic resonance elastography after chronic spinal cord injury: a cross-sectional pilot study

磁共振弹性成像评估慢性脊髓损伤后的骨骼肌硬度

Mina P. Ghatas, M. Rehan Khan, Ashraf S. Gorgey

神经退行性疾病与神经再生

Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson’s disease

应激增加多巴胺能神经元中MHC-I表达诱导帕金森病的自身免疫

Bao-Yan Wang, Yong-Yi Ye, Chen Qian, Hong-Bo Zhang, Heng-Xu Mao, Long-Ping Yao, Xiang Sun, Guo-Hui Lu, Shi-Zhong Zhang

P2X4 receptor participates in autophagy regulation in Parkinson’s disease

P2X4受体参与调节帕金森病的自噬

Xue Zhang, Jing Wang, Jin-Zhao Gao, Xiao-Na Zhang, Kai-Xin Dou, Wan-Da Shi, An-Mu Xie

Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias: a retrospective casecontrol study

血管紧张素转化酶抑制剂和AT1受体阻滞剂可减少左旋多巴诱发运动障碍的发生

Elena Contaldi, Luca Magistrelli, Anna V. Milner, Marco Cosentino, Franca Marino, Cristoforo Comi

11C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls: a cross-sectional study

多发性硬化患者和健康对照11C-PK11195血浆代谢率相同

Aline Morais de Souza, Milena Sales Pitombeira, Larissa Estessi de Souza, Fabio Luiz Navarro Marques, Carlos Alberto Buchpiguel, Caroline Cristiano Real, Daniele de Paula Faria

Effects of a multimodal exercise protocol on functional outcomes, epigenetic modulation and brainderived neurotrophic factor levels in institutionalized older adults: a quasi-experimental pilot study

养老机构老年人多模式锻炼方案对其生活质量、表观遗传标记和脑源性神经营养因子的影响

Iasmin Fraga, Camila Weber, Wériton Baldo Galiano, Lucio Iraci, Mariana Wohlgemuth, Gabriela Morales,Camila Cercato, Juliana Rodriguez, Daniela Pochmann, Caroline Dani, Pérsia Menz, Adriane Dal Bosco, Viviane Rostirola Elsner

周围损伤与神经再生

Inhibitor of DNA binding 2 accelerates nerve regeneration after sciatic nerve injury in mice

DNA结合抑制剂2加速小鼠损伤坐骨神经的再生

Zhong-Hai Huang, Ai-Ying Feng, Jing Liu, Libing Zhou, Bing Zhou, Panpan Yu

Structural remodeling in related brain regions in patients with facial synkinesis

面肌联动患者存在相关脑区结构重塑现象

Jia-Jia Wu, Ye-Chen Lu, Mou-Xiong Zheng, Xu-Yun Hua, Chun-Lei Shan, Wei Ding, Jian-Guang Xu

视神经损伤与神经再生

Gene therapy with caspase-3 small interfering RNA-nanoparticles is neuroprotective after optic nerve damage

非病毒的caspase-3 siRNA纳米粒子基因治疗可保护损伤的视神经

Mohamed Tawfik, Xiwei Zhang, Lisa Grigartzik, Peter Heiduschka, Werner Hintz, Petra Henrich-Noack, Berend van Wachem, Bernhard A. Sabel

Letter to the editor

CD4 + Tregs may be essential for solving astrocyte glial scar deadlock

CD4+Tregs可能是解决星形胶质细胞瘢痕死锁的必要条件

Michel Edwar-Mickael, Norwin Kubick | Bevill Biomedical Sciences Research, USA