2023年第4期

www.nrronline.org

NEURAL REGENERATION RESEARCH

Vol 18｜No. 4｜April 2023

综述 /

MicroRNAs: protective regulators for neuron growth and development

微小RNA：神经元生长和发育过程中的保护性调节器

Zhi-Xuan Ma, Zhen Liu, Hui-Hui Xiong, Zong-Pu Zhou, Li-Si Ouyang, Fu-Kang Xie, Ya-Mei Tang, Zhong-Dao Wu, Ying Feng

Novel insights into the mechanism of reactive oxygen species-mediated neurodegeneration

对活性氧介导的神经变性机制的新见解

Shuji Wakatsuki, Toshiyuki Araki

Potential physiological and pathological roles for axonal ryanodine receptors

轴突兰尼碱受体的潜在生理和病理作用

David P. Stirling

In vivo astrocyte-to-neuron reprogramming for central nervous system regeneration: a narrative review

星形胶质细胞转化为神经元的体内重编程

Zuliyaer Talifu, Jia-Yi Liu, Yun-Zhu Pan, Han Ke, Chun-Jia Zhang, Xin Xu, Feng Gao, Yan Yu, Liang-Jie Du, Jian-Jun Li

Melatonin, tunneling nanotubes mesenchymal cells and tissue regeneration

褪黑激素、隧道纳米管间充质细胞和组织再生

Francesca Luchetti, Silvia Carloni, Maria G. Nasoni, Russel J. Reiter, Walter Balduini

组成型分泌的细胞外分子伴侣在神经元修复和再生中的作用

Sandeep Satapathy, Mark R. Wilson

Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury

用于预防和恢复创伤性脑损伤结果的鼻内神经生长因子

Luigi Manni, Giorgio Conti, Antonio Chiaretti, Marzia Soligo

Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain

GPR109A 在调节神经系统疾病和疼痛中神经炎症的新作用

Kyle Taing, Lawrence Chen, Han-Rong Weng

MicroRNAs as potential biomarkers in temporal lobe epilepsy and mesial temporal lobe epilepsy

MicroRNAs 作为颞叶癫痫和颞叶内侧癫痫的潜在生物标志物

Bridget Martinez, Philip V. Peplow

Altered O-GlcNAcylation and mitochondrial dysfunction, a molecular link between brain glucose dysregulation and sporadic Alzheimer’s disease

改变的 O-GlcNAcylation 和线粒体功能障碍，脑葡萄糖失调和散发性阿尔茨海默病之间的分子联系

Chia-Wei Huang, Nicholas C. Rust, Hsueh-Fu Wu, Gerald W. Hart

Agomelatine: a potential novel approach for the treatment of memory disorder in neurodegenerative disease

治疗神经退行性疾病记忆障碍的新型药物：阿戈美拉汀

Qiang Su, Tian Li, Guo-Wei Liu, Yan-Li Zhang, Jun-Hong Guo, Zhao-Jun Wang, Mei-Na Wu, Jin-Shun Qi

Signaling interactions among neurons impact cell fitness and death in Alzheimer’s disease

神经元之间的信号相互作用影响阿尔茨海默病的细胞适应性和死亡

Catherine Yeates, Prajakta Deshpande, Madhuri Kango-Singh, Amit Singh

Targeting neuroinflammation in Alzheimer’s disease: from mechanisms to clinical applications

靶向神经炎症的阿尔茨海默病：从机制到临床应用

Zi-Zhen Si, Chen-Jun Zou, Xi Mei, Xiao-Fang Li, Hu Luo, Yao Shen, Jun Hu, Xing-Xing Li, Lun Wu, Yu Liu

Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events

慢性压迫性脊髓损伤的血管事件及其病理生理学机制

Zhen-Xiao Ren, Jing-Hui Xu, Xing Cheng, Gui-Xing Xu, Hou-Qing Long

Neural and Müller glial adaptation of the retina to photoreceptor degeneration

视网膜对光感受器变性的神经和 Müller 胶质细胞适应

Henri O. Leinonen, Edward Bull, Zhongjie Fu

观点 /

Next generation drug connectivity mapping for acquiring therapeutic agents to differentially regulate myelination

用于获取治疗剂以差异调节髓鞘形成的下一代药物连接图

Kasum Azim, Andrea Domenico Rivera, Arthur Morgan But

Functional phenotyping of microglia highlights the dark relationship between chronic traumatic brain injury and normal age-related pathology

小胶质细胞的功能表型突出了慢性创伤性脑损伤与正常年龄相关病理学之间的黑暗关系

Rodney M. Ritzel, Junfang Wu

Acute and long-term changes in blood flow after ischemic stroke: challenges and opportunities

缺血性卒中后血流的急性和长期变化：挑战和机遇

Dino Premilovac, Brad A. Sutherland

Pathology-induced NG2 proteoglycan expression in microglia

病理学诱导的小胶质细胞中 NG2 蛋白多糖的表达

Erika Meyer, Anja Scheller

Multi-targeted anti-inflammatory drugs for the treatment of neurological disorders

用于治疗神经系统疾病的多靶点抗炎药

Austin Lui, Omar Alzayat, Timothy Do, David Perekopskiy, Meghan Gann, Taiseer Saad Elgokhy, Jie Gao, DaZhi Liu

Nilotinib: from animal-based studies to clinical investigation in Alzheimer’s disease patients

尼罗替尼：从动物研究到阿尔茨海默病患者的临床研究

Annalisa Nobili, Marcello D’Amelio, Maria Teresa Viscomi

Emerging non-invasive therapeutic approaches targeting hypocholinergic neural systems in Parkinson’s disease

针对帕金森病的低胆碱能神经系统的新兴非侵入性治疗方法

Nicolaas I. Bohnen, Alison J. Yarnall

Taurine: an essential amino sulfonic acid for retinal health

牛磺酸：一种对视网膜健康至关重要的氨基磺酸

Johnny Di Pierdomenico, Ana Martínez-Vacas, Serge Picaud, María P. Villegas-Pérez, Diego García-Ayuso

研究原著 /

中枢神经系统损伤与神经再生

Spliceosomal GTPase Eftud2 regulates microglial activation and polarization

剪接体GTP酶Eftud2可调节炎症反应中小胶质细胞的活化和极化

Guo-Chao Yang, Yuan Shi, Chao-Nan Fan, Ying Li, Meng-Qi Yuan, Jie Pei, Yan Wu, Hai-Tao Wu

Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair

多聚鸟氨酸可阻断纤连蛋白对少突胶质细胞分化的抑制而促进髓鞘修复

Ya-Jie Xiong, Shahid Hussain Soomro, Zhong-Hai Huang, Pan-Pan Yu, Jie Ping, Hui Fu

脑损伤与神经再生

DNA hypomethylation promotes learning and memory recovery in a rat model of cerebral ischemia/reperfusion injury

抑制DNA甲基化可促进脑缺血再灌注模型大鼠恢复学习和记忆功能

Guang Shi, Juan Feng, Ling-Yan Jian, Xin-Yu Fan

Vagus nerve stimulation is a potential treatment for ischemic stroke

迷走神经刺激是治疗缺血性脑卒中的潜在方法

Yi-Lin Liu, San-Rong Wang, Jing-Xi Ma, Le-Hua Yu, Gong-Wei Jia

Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury

芬戈尔莫德减轻局灶性缺血再灌注损伤大鼠神经血管单元损伤

Xiao-Yu Zhu, Ting-Ting Ma, Yang Li, Ming-Qi Zhang, Liang Zhao, Jia Liang, Lian-Qiu Min

Cyclophilin D-induced mitochondrial impairment confers axonal injury after intracerebral hemorrhage in mice

亲环素D诱导的线粒体损伤可造成小鼠脑出血后轴突损伤

Yang Yang, Kai-Yuan Zhang, Xue-Zhu Chen, Chuan-Yan Yang, Ju Wang, Xue-Jiao Lei, Yu-Lian Quan, Wei-Xiang Chen,Heng-Li Zhao, Li-Kun Yang, Yu-Hai Wang, Yu-Jie Chen, Hua Feng

Alpha2-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injury

α2-肾上腺素能受体激活可恢复大脑皮质损伤大鼠的运动功能

Gabriela García-Díaz, Laura E. Ramos-Languren, Carmen Parra-Cid, Joel Lomelí, Sergio Montes, Camilo Ríos, Antonio Bueno-Nava, Ignacio Valencia-Hernández, Rigoberto González-Piña

脊髓损伤与神经再生

Erythropoietin inhibits ferroptosis and ameliorates neurological function after spinal cord injury

促红细胞生成素可抑制铁死亡改善脊髓损伤后的神经功能

Yu Kang, Rui Zhu, Shuang Li, Kun-Peng Qin, Hao Tang, Wen-Shan Shan, Zong-Sheng Yin

Circulating exosomal lncRNA contributes to the pathogenesis of spinal cord injury in rats

大鼠脊髓损伤病理过程相关的循环外泌体lncRNA

Jian-An Li, Ming-Peng Shi, Lin Cong, Ming-Yu Gu, Yi-Heng Chen, Si-Yi Wang, Zhen-Hua Li, Chun-Fang Zan, Wan-Fu Wei

Safety and effectiveness of electromyography-induced rehabilitation treatment after epidural electrical stimulation for spinal cord injury: study protocol for a prospective, randomized, controlled trial

脊髓损伤硬膜外电刺激治疗后肌电诱导康复的安全及有效性：前瞻性、单中心、随机、对照、临床试验方案

Xiao-Pei Sun, Jie-Jian Shi, Yong Bao, Jie Zhang, Hui-Juan Pan, Dian-You Li, Yu Liang, Qing Xie

Oscillating field stimulation promotes neurogenesis of neural stem cells through miR-124/Tal1 axis to repair spinal cord injury in rats

振荡电场刺激促进神经干细胞神经生成修复大鼠脊髓损伤

Chao Fang, Jian Sun, Jun Qian, Cai-Liang Shen

神经退行性疾病与神经再生

Sex modulates the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson’s disease

丘脑底核脑深部电刺激治疗帕金森病效果的性别差异

Tian-Shuo Yuan, Ying-Chuan Chen, De-Feng Liu, Ruo-Yu Ma, Xin Zhang, Ting-Ting Du, Guan-Yu Zhu, Jian-Guo Zhang

Promising application of a new ulnar nerve compound muscle action potential measurement montage in amyotrophic lateral sclerosis: a prospective cross-sectional study

一种新型尺神经复合肌肉动作电位测量模式在肌萎缩侧索硬化中的应用：前瞻性横断面研究

Yi-Xuan Zhang, Jing-Yue Ma, Xiang-Yi Liu, Shuo Zhang, Zhou Yu, Dong-Sheng Fan

周围神经损伤与神经再生

Regenerative peripheral nerve interface prevents neuroma formation after peripheral nerve transection

再生坐骨周围神经横断后接口可防止神经瘤形成

Zheng Wang, Xin-Zeyu Yi, Ai-Xi Yu

视神经损伤与神经再生

Siponimod exerts neuroprotective effects on the retina and higher visual pathway through neuronal S1PR1 in experimental glaucoma

西尼莫德通过神经元S1PR1对实验性青光眼的视网膜和高级视觉通路的神经保护

Devaraj Basavarajappa, Vivek Gupta, Nitin Chitranshi, Roshana Vander Wall, Rashi Rajput, Kanishka Pushpitha, Samridhi Sharma, Mehdi Mirzaei, Alexander Klistorner, Stuart L. Graham

Use of a tissue clearing technique combined with retrograde transsynaptic viral tracing to evaluate changes in mouse retinorecipient brain regions following optic nerve crush

透明化处理联合逆向跨突触病毒示踪分析视神经挤压小鼠大脑中视网膜受体区域的变化

Zong-Yi Zhan, Yi-Ru Huang, Lu-Wei Zhao, Ya-Dan Quan, Zi-Jing Li, Di-Fang Sun, Ya-Li Wu, Hao-Yuan Wu, Zi-Tian Liu, Kai-Li Wu, Yu-Qing Lan, Min-Bin Yu

Necroptosis plays a crucial role in the exacerbation of retinal injury after blunt ocular trauma

坏死性凋亡在加重眼钝挫伤后视网膜损伤的重要作用

Yu Huan, Xiu-Quan Wu, Tao Chen, Ya-Nan Dou, Bo Jia, Xin He, Dong-Yu Wei, Zhou Fei, Fei Fei