[1] Del Negro C A, Funk G D, Feldman J L. Breathing matters[J].  Nat Rev Neurosci, 2018, 19(6):351-367.

[2] Jonkman A H, de Vries H J, Heunks L M A. Physiology of the Respiratory Drive in ICU Patients: Implications for Diagnosis and Treatment[J]. Crit Care, 2020, 24(1):104. 

[3] Spinelli E, Mauri T, Beitler J R, et al. Respiratory drive in the acute respiratory distress syndrome: pathophysiology, monitoring, and therapeutic interventions[J]. Intensive Care Med, 2020, 46(4):606-618.

[4] Mascheroni D, Kolobow T, Fumagalli R, et al. Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study[J]. Intensive Care Med, 1988, 15:8-14.

[5] Yoshida T, Uchiyama A, Matsuura N, et al. The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury[J]. Crit Care Med, 2013, 41(2):536-545.

[6] Gainnier M, Roch A, Forel JM, et al. Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome[J]. Crit Care Med, 2004, 32(1):113-119.

[7] Forel J M, Roch A, Marin V, et al. Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome[J]. Crit Care Med, 2006, 34(11):2749-2757.

[8] Papazian L, Forel J M, Gacouin A, et al. Neuromuscular blockers in early acute respiratory distress syndrome[J]. N Engl J Med, 2010, 363(12):1107-1116.

[9] Steingrub J S, Lagu T, Rothberg M B, et al. Treatment with neuromuscular blocking agents and the risk of in-hospital mortality among mechanically ventilated patients with severe sepsis[J]. Crit Care Med, 2014, 42(1):90-96.

[10] Yoshida T, Amato M B P, Kavanagh B P, et al. Impact of spontaneous breathing during mechanical ventilation in acute respiratory distress syndrome[J]. Curr Opin Crit Care, 2019, 25(2):192-198.

[11] Yoshida T, Fujino Y, Amato M B, et al. Fifty Years of Research in ARDS. Spontaneous Breathing during Mechanical Ventilation. Risks, Mechanisms, and Management[J]. Am J Respir Crit Care Med, 2017, 195(8):985-992.

[12] Yoshida T, Uchiyama A, Fujino Y. The role of spontaneous effort during mechanical ventilation: normal lung versus injured lung[J]. J Intensive Care, 2015, 3:18.

[13] Blanch L, Villagra A, Sales B, et al. Asynchronies during mechanical ventilation are associated with mortality[J]. Intensive Care Med, 2015, 41(4):633-641.

[14] Jiang T X, Reid W D, Belcastro A, et al. Load dependence of secondary diaphragm inflammation and injury after acute inspiratory loading[J]. Am J Respir Crit Care Med, 1998, 157(1):230-236.

[15] Goligher E C, Fan E, Herridge M S, et al. Evolution of Diaphragm Thickness during Mechanical Ventilation. Impact of Inspiratory Effort[J]. Am J Respir Crit Care Med, 2015, 192(9):1080-1088.

[16] 中华医学会呼吸病学分会呼吸危重症医学学组. 急性呼吸窘迫综合征患者机械通气指南(试行)[J]. 中华医学杂志, 2016, 96(6): 404-424. 

[17] Papazian L, Aubron C, Brochard L, et al. Formal guidelines: management of acute respiratory distress syndrome[J]. Ann Intensive Care, 2019, 9(1):69.

[18] Griffiths M, Fan E, Baudouin S V. New UK guidelines for the management of adult patients with ARDS[J]. Thorax, 2019, 74(10):931-933.

[19] Griffiths M J D, McAuley D F, Perkins G D, et al. Guidelines on the management of acute respiratory distress syndrome[J]. BMJ Open Respir Res, 2019, 6(1):e000420.

[20] Alhazzani W, Belley-Cote E, Møller M H, et al. Neuromuscular blockade in patients with ARDS: a rapid practice guideline[J]. Intensive Care Med, 2020, 46(11):1977-1986.