The region of the Arab Middle East known as the Levant is located on the continent of southwestern Asia and includes the people of Lebanon, Syria, Israel/Palestine, and Jordan. The focus of this chapter is on the immigration of families from this region to the United States and Canada. This chapter provides a summary of the culture and values that the people of these regions bring with them when they immigrate to North America, as well as the currently available demographic patterns of data. Mental health and family vulnerability issues are reviewed given the potential histories of wartime trauma and post-migration acculturative stresses, including prejudice and discrimination experienced by those from the Levant. The implications of adverse life circumstances for adaptation and resilient functioning are highlighted in the context of acculturation issues, preventative interventions, and future research agendas.