Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury

靶向mTOR途径大脑传递RNA治疗实现中枢神经系统损伤后的轴突再生

Ming-Xi Li, Jing-Wen Weng, Eric S. Ho, Shing Fung Chow, Chi Kwan Tsang

Exploring the role of interleukin-27 as a regulator of neuronal survival in central nervous system diseases

探索白细胞介素 27 在中枢神经系统疾病中作为神经元存活调节剂的作用

Andrea N. Nortey, Kimberly N. Garces, Abigail S. Hackam

Potential significance of CX3CR1 dynamics in stress resilience against neuronal disorders

CX3CR1 动力学在对抗神经元疾病的压力恢复中的潜在意义

Koichi Inoue

Unraveling pathological mechanisms in neurological disorders: the impact of cell-based and organoid models

揭示神经系统疾病的病理机制：基于细胞和类器官模型的影响

Jake Langlie, Rahul Mittal, Ariel Finberg, Nathalie B. Bencie, Jeenu Mittal, Hossein Omidian, Yadollah Omidi, Adrien A. Eshraghi

Biomaterial and tissue-engineering strategies for the treatment of brain neurodegeneration

用于治疗脑神经变性的生物材料和组织工程策略

Bridget Martinez, Philip V. Peplow

Role of platelet-derived extracellular vesicles in traumatic brain injuryinduced coagulopathy and inflammation

血小板源性细胞外囊泡对创伤性脑损伤诱导凝血功能障碍和炎症反应中的作用

Liang Liu, Quan-Jun Deng

Status of precision medicine approaches to traumatic brain injury: a review

创伤性脑损伤：基于精确医学的高风险个体识别及个性化治疗

Sahithi Reddi, Smita Thakker-Varia, Janet Alder, Anna O. Giarratana

Polyphenols as potential enhancers of stem cell therapy against neurodegeneration

多酚类物质作为干细胞治疗神经退行性的潜在增强剂

Diana Rodríguez-Vera, Antonio Abad-García, Nancy Vargas-Mendoza, Rodolfo Pinto-Almazán, Eunice D. Farfán-García, José A. Morales-González, Marvin A. Soriano-Ursúa

WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder

强迫症WNT/β-catenin 通路和昼夜节律

Alexandre Vallée, Yves Lecarpentier, Jean-Noël Vallée

Respiratory plasticity following spinal cord injury: perspectives from mouse to man

脊髓损伤后呼吸可塑性：从小鼠到人类

Katherine C. Locke, Margo L. Randelman, Daniel J. Hoh, Lyandysha V. Zholudeva, Michael A. Lane

Graphene and graphene-based materials in axonal repair of spinal cord injury

脊髓损伤轴突修复过程中石墨烯及其衍生物的优势

Shi-Xin Wang, Yu-Bao Lu, Xue-Xi Wang, Yan Wang, Yu-Jun Song, Xiao Wang, Munkhtuya Nyamgerelt

Role of adipose tissue grafting and adipose-derived stem cells in peripheral nerve surgery

脂肪组织移植和脂肪干细胞在周围神经手术中的作用

Tiam M. Saffari, Sara Saffari, Krishna S. Vyas, Samir Mardini, Alexander Y. Shin

Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation

周围神经损伤的基本机制和电刺激治疗

Xiao-Lei Chu, Xi-Zi Song, Qi Li, Yu-Ru Li, Feng He, Xiao-Song Gu, Dong Ming

Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy

糖尿病性角膜神经病变作为糖尿病周围神经病变的替代标志物

Wei Zheng So, Natalie Shi Qi Wong, Hong Chang Tan, Molly Tzu Yu Lin, Isabelle Xin Yu Lee, Jodhbir S. Mehta, Yu-Chi Liu

Exploiting Caenorhabditis elegans to discover human gut microbiota-mediated intervention strategies in protein conformational diseases

利用秀丽隐杆线虫发现人类肠道微生物群介导的蛋白质构象疾病干预策略

Daniel M. Czyż

Functional in vivo assessment of stem cell-secreted pro-oligodendroglial factors

干细胞分泌的前少突胶质细胞因子的体内功能评估

Jessica Schira-Heinen, Iria Samper Agrelo, Veronica Estrada, Patrick Küry

Synergia of human platelet lysate and laminin to enhance the neurotrophic effect of human adipose-derived stem cells

人血小板裂解物和层粘连蛋白的协同作用增强人脂肪干细胞的神经营养作用

Pietro G di Summa, Srinivas Madduri

Brain-derived cell-free DNA

脑源性无细胞 DNA

Dean Southwood, Sanyukta Singh, Zac Chatterton

Complement activation kindles the transition of acute post-traumatic brain injury to a chronic inflammatory disease

补体激活引发急性创伤后脑损伤向慢性炎症性疾病的转变

Andrew Erwood, Ali M. Alawieh

Transcranial electrical stimulation in neurological disease

神经系统疾病中的经颅电刺激

Gregory L. Brown, Michael T. Brown

Ionotropic glutamatergic receptor expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in Alzheimer’s disease

阿尔茨海默病海马、下叶、内嗅皮层和颞上回的离子型谷氨酸能受体表达

Jason HY Yeung, Henry J Waldvogel, Richard LM Faull, Andrea Kwakowsky

How useful are biomarkers for the diagnosis of Alzheimer's disease and especially for its therapy?

生物标志物对阿尔茨海默病的诊断，尤其是其治疗有多大用处？

Marta Valenza, Caterina Scuderi

N-methyl-D-aspartate receptor functions altered by neuronal PTP1B activation in Alzheimer’s and schizophrenia models

阿尔茨海默病和精神分裂症模型中神经元 PTP1B 激活改变N-甲基-D-天冬氨酸受体功能

Alexandre F. R. Stewart, Hsiao-Huei Chen

The integrative role of G protein-coupled receptor heterocomplexes in Parkinson´s disease

G蛋白偶联受体异源复合物在帕金森病中的整合作用

Dasiel O. Borroto-Escuela, Kjell Fuxe

Aminopeptidase A and dipeptidyl peptidase 4: a pathogenic duo in Alzheimer’s disease?

氨基肽酶 A 和二肽基肽酶 4：阿尔茨海默病的致病二重奏？

Frédéric Checler, Audrey Valverde

Ubiquitin homeostasis disruption, a common cause of proteostasis collapse in ALS?

泛素平衡的破坏，是ALS中蛋白状态崩溃的一个共同原因？

Christen G. Chisholm, Jeremy S. Lum, Natalie E. Farrawell, Justin J. Yerbury

Zinc finger protein ZPR1: promising survival motor neuron-dependent modifier for the rescue of spinal muscular atrophy

锌指蛋白 ZPR1：拯救脊髓性肌萎缩症的运动神经元存活依赖调节剂

Juliana Cuartas, Laxman Gangwani

Novel insights into the pathogenesis of tendon injury: mechanotransduction and neuroplasticity

肌腱损伤发病机制的新见解：机械转导和神经可塑性

Suellen Alessandra Soares de Moraes

Degeneration of retinal ganglion cells in hypoxic responses: hypoxia-inducible factor inhibition, a new insight as a therapeutic target

缺氧反应中视网膜神经节细胞的退化：缺氧诱导因子抑制，作为治疗靶点的新见解

Deokho Lee, Hiromitsu Kunimi, Kazuno Negishi, Toshihide Kurihara

脑损伤与神经再生

The delivery of miR-21a-5p by extracellular vesicles induces microglial polarization via the STAT3 pathway following hypoxia-ischemia in neonatal mice

缺氧缺血性脑损伤细胞外囊泡输送的miR-21a-5p介导小胶质细胞分化

Dan-Qing Xin, Yi-Jing Zhao, Ting-Ting Li, Hong-Fei Ke, Cheng-Cheng Gai, Xiao-Fan Guo, Wen-Qiang Chen, De-Xiang Liu, Zhen Wang

Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function

射线损害海马CA1区锥体神经元的兴奋性放电及突触可塑性

Min-Yi Wu, Wen-Jun Zou, Pei Yu, Yuhua Yang, Shao-Jian Li, Qiang Liu, Jiatian Xie, Si-Qi Chen, Wei-Jye Lin, Yamei Tang

Temporal alterations in pericytes at the acute phase of ischemia/reperfusion in the mouse brain

脑缺血再灌注急性期周细胞的时程变化

Shuang Zhang, Xue-Jing Liao, Jia Wang, Yi Shen, Han-Fen Shi, Yan Zou, Chong-Yang Ma, Xue-Qian Wang, Qing-Guo Wang, Xu Wang, Ming-Yang Xu, Fa-Feng Cheng, Wan-Zhu Bai

Bradykinin postconditioning protects rat hippocampal neurons after restoration of spontaneous circulation following cardiac arrest via activation of the AMPK/mTOR signaling pathway

缓激肽可保护心脏骤停恢复自主循环后的海马神经元

Shi-Rong Lin, Qing-Ming Lin, Yu-Jia Lin, Xin Qian, Xiao-Ping Wang, Zheng Gong, Feng Chen, Bin Song

A neurovascular unit-on-a-chip: culture and differentiation of human neural stem cells in a threedimensional microfluidic environment

神经-血管单元模型：在三维微流体环境中实现人神经干细胞的培养和分化

Wen-Juan Wei, Ya-Chen Wang, Xin Guan, Wei-Gong Chen, Jing Liu

脊髓损伤与神经再生

The functional properties of synapses made by regenerated axons across spinal cord lesion sites in lamprey

七鳃鳗脊髓病变部位再生轴突的生理学功能特性

David Parker

A comparative analysis of differentially expressed genes in rostral and caudal regions after spinal cord injury in rats

大鼠损伤脊髓远端和近端基因表达的差异

Xue-Min Cao, Sheng-Long Li, Yu-Qi Cao, Ye-Hua Lv, Ya-Xian Wang, Bin Yu, Chun Yao

Expression and regulatory network of long noncoding RNA in rats after spinal cord hemisection injury

大鼠脊髓半横断损伤后长链非编码RNA的表达及调控网络

Wei Liu, Jin-Cheng Tao, Sheng-Ze Zhu, Chao-Lun Dai, Ya-Xian Wang, Bin Yu, Chun Yao, Yu-Yu Sun

神经退行性疾病与神经再生

Anodal transcranial direct current stimulation alleviates cognitive impairment in an APP/PS1 model of Alzheimer’s disease in the preclinical stage

经颅直流电刺激干预可长期改善阿尔茨海默病临床前阶段APP/PS1小鼠的认知障碍

Yin-Pei Luo, Zhi Liu, Cong Wang, Xiu-Fang Yang, Xiao-Ying Wu, Xue-Long Tian, Hui-Zhong Wen

DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer’s disease

DNA疫苗靶向淀粉样蛋白β寡聚体可改善老年APP/PS1/tau三转基因阿尔茨海默病小鼠的认知缺陷

Sha Sha, Xiao-Na Xing, Tao Wang, Ying Li, Rong-Wei Zhang, Xue-Li Shen, Yun-Peng Cao, Le Qu

SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease

SARM1可参与朊病毒疾病中轴突变性和线粒体功能障碍

Meng-Yu Lai, Jie Li, Xi-Xi Zhang, Wei Wu, Zhi-Ping Li, Zhi-Xin Sun, Meng-Yang Zhao, Dong-Ming Yang, Dong-Dong Wang, Wen Li, De-Ming Zhao, Xiang-Mei Zhou, Li-Feng Yang

Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Drosophila model

淀粉样β蛋白和Tau毒性在果蝇模型中的相互增强

Zhen-Dong Sun, Jia-Xin Hu, Jia-Rui Wu, Bing Zhou, Yun-Peng Huang

神经再生技术

Magnetic labeling of primary murine monocytes using very small superparamagnetic iron oxide nanoparticles

超小超顺磁氧化铁纳米颗粒标记鼠原代培养单核细胞

Martin Pohland, Christoph Pohland, Jürgen Kiwit, Jana Glumm

Alexa Fluor 488-conjugated cholera toxin subunit B optimally labels neurons 3–7 days after injection into the rat gastrocnemius muscle

霍乱毒素亚单位B结合荧光素在大鼠腓肠肌注射后3-7d时可观察到标记神经元的最佳形态

Jing-Jing Cui, Jia Wang, Dong-Sheng Xu, Shuang Wu, Ya-Ting Guo, Yu-Xin Su, Yi-Han Liu, Yu-Qing Wang, Xiang-Hong Jing, Wan-Zhu Bai